I am lost.

American Sign Language:
I am http://commtechlab.msu.edu/sites/aslweb/I/W1707.htm
lost. http://commtechlab.msu.edu/sites/aslweb/L/W2160.htm

English:
I am lost.

French:
Je me suis perdue.

Italian:
Mi sono perso. (male)
Mi sono persa. (female)

Spanish:
Estoy perdido.

Swahili:
Sitilifika.