What is that?

American Sign Language:
What (is) http://commtechlab.msu.edu/sites/aslweb/W/W4456.htm
that? http://commtechlab.msu.edu/sites/aslweb/T/W4103.htm

English:
What is that?

French:
Qu'est-ce que c'est?

Italian:
Che cosa è quello?

Spanish:
¿Qué es eso?

Swahili:
Hiki ni nini?